Metabolism

Topic 8.1

Essential idea: Metabolic reactions are regulated in response to the cell's needs.

Understandings

8.1.U1 Metabolic pathways consist of chains and cycles of enzyme-catalyzed reactions

Metabolic pathways involve chains and cycles

8.1.U2 Enzymes lower the activation energy of the chemical reactions that they catalyze

Elongation process in translation

8.1.U3 Enzyme inhibitors can be competitive or noncompetitive

Comparing competitive and noncompetitive inhibitors

8.1.U4 Metabolic pathways can be controlled by an product inhibition

Description of end-product inhibition

Applications

8.1.A1 End-product inhibition of the pathway that converts threonine to isoleucine

End-product inhibition by isoleucine

8.1.A2 Use of databases to identify potential new anti-malarial drugs

Why are databases important?

Questions regarding SL gene pairs and database searches

Questions: SL gene pairs

Place your mouse on the question to view how a search for possible new antimalarial drugs is carried out

How to carry out a databasesearch for SL gene pairs

Skills

8.1.S1 Calculating and plotting rates of reaction from raw experimental results

Place your mouse on the diagram to view the calculation of reaction rate

How to calculate reaction rate

8.2.S2 Distinguishing different types of inhibition from graphs at specified substrate concentration

Place your mouse on the diagram to view the mechanisms of action for competitive and noncompetitive inhibitors

Competitive and noncompetitive graphs explained
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